The MGST1 and DERA eQTLs explained large proportions of the phenotypic and genetic variance in gene expression, with the top associated MGST1 variant explaining 60.7% and 88.8% respectively, and the top DERA variant explaining 18.8% and 59.1% respectively. Peak signal for DERA expression was 500kbp downstream of the milk composition signals, deriving from a cluster of 10 variants spanning the first intron, 5UTR, and non coding sequence immediately upstream of the DERA TSS (Fig. 5D).
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